Measure

CDAI^1,2

Components

Score

Low DA: >2.8 to 10

Moderate DA: >10 to 22

High DA: >22

Attributes

• Good hypotheses testing and responsiveness
• Generally reliable and structurally valid
• No lab testing required
• Correlates with ACR response, DAS28, joint damage, and HAQ

Measure

SDAI^1,2

Components

Score

Low DA: >3.3 to ≤11.0

Moderate DA: >11.0 to ≤26

High DA: >26

Attributes

• Good hypotheses testing and responsiveness
• Generally reliable
• Requires lab testing
• Correlates with ACR response, DAS28, joint damage, and HAQ

Measure

DAS28-ESR/CRP^1,3

Components

Score

Low DA: 2.6 to <3.2

Moderate DA: 3.2 to ≤5.1

High DA: >5.1

Attributes

• Good hypotheses testing and responsiveness
• Generally reliable, structurally valid, and internally consistent
• Moderate measurement error and less stringent definition of remission than CDAI and SDAI
• Requires lab testing
• In early RA (disease duration <5 years), patients achieving remission (DAS28 <2.6) have better function, QoL, and structural outcomes than patients with low DA

Measure

RAPID3^1,4,5

Components

Score

Low DA: 4 to 6

Moderate DA: 7 to 12

High DA: ≥13

Attributes

• Good hypotheses testing, content validity, and responsiveness
• Easy to incorporate in clinic because patient-driven, not needing physician assessments
• Calculated in just 5-10 seconds
• Significantly correlated with CDAI and DAS28

Measure

PAS-II^1,4

Components

Score

Low DA: >0.26 to 3.70

Moderate DA: 3.71 to <8.0

High DA: ≥8.0

Attributes

• Easy to incorporate in clinic because patient-driven, not needing physician assessments
• Did not meet minimum standard for regular use due to inadequate psychometrics*
• Uses HAQ-II, which is shorter than HAQ