Essential immunological functions depend on the dynamic equilibrium of the JAK-STAT pathway.1
Physiological disruptions and inflammatory diseases, such as RA, have been associated with deficient and excessive JAK-STAT pathway signalling, respectively.2-13
HCP, healthcare provider; JAK, Janus kinase; RA, rheumatoid arthritis; STAT, signal transducer and activator of transcription.
REFERENCES
1. Villarino AV, Kanno Y, Ferdinand JR, O'Shea JJ. J Immunol. 2015;194(1):21-27. 2. Schwartz DM, Kanno Y, Villarino A, Ward M, Gadina M, O'Shea JJ. Nat Rev Drug Discov. 2017;16(12):843-862. 3. Park SO, Wamsley HL, Bae K, et al. PLoS One. 2013;8(3):e59675. 4. Gotthardt D, Sexl V. Front Immunol. 2016;7:694. 5. Bottos A, Gotthardt D, Gill JW, et al. Nat Commun. 2016;7:12258. 6. Wang KS, Zorn E, Ritz J. Blood. 2001;97(12):3860-3866. 7. Hashizume M, Hayakawa N, Mihara M. Rheumatology (Oxford). 2008;47(11):1635-1640. 8. McInnes IB, Leung BP, Sturrock RD, Field M, Liew FY. Nat Med. 1997;3(2):189-195. 9. Ferrari-Lacraz S, Zanelli E, Neuberg M, et al. J Immunol. 2004;173(9):5818-5826. 10. González-Alvaro I, Domínguez-Jiménez C, Ortiz AM, et al. Arthritis Res Ther. 2006;8(4):R88. 11. Li J, Shen W, Kong K, Liu Z. Scand J Immunol. 2006;64(5):515-522. 12. Xing R, Yang L, Jin Y, et al. Scand J Immunol. 2016;83(1):64-71. 13. Kwok SK, Cho ML, Park MK, et al. Arthritis Rheum. 2012;64(3):740-751. 14. Dinesh P, Rasool M. J Cell Physiol. 2018;233(5):3918-3928. 15. Chen Z, Han Y, Gu Y, et al. J Immunol. 2013;190(12):5256-5266. 16. Schwartz DM, Bonelli M, Gadina M, O'Shea JJ. Nat Rev Rheumatol. 2016;12(1):25-36. 17. Winthrop KL. Nat Rev Rheumatol. 2017;13(4):234-243. 18. O’Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A. Annu Rev Med. 2015;66:311-328.
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