The JAK-STAT pathway mediates both normal physiological functions and inflammatory responses. 1-3
Emerging research continues to elucidate how the JAK-STAT pathway plays important roles in homeostasis and inflammatory diseases such as UC. 1-3
• Four JAK proteins – JAK1, JAK2, JAK3, and TYK2 – mostly form pairs that mediate cytokine signalling.2,3
• Multiple cytokines bind to their associated receptors to signal through the JAK-STAT pathway.2-4
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